Studies on the photohydrates of cytosine and its derivatives. by Gerrit De Boer

Cover of: Studies on the photohydrates of cytosine and its derivatives. | Gerrit De Boer

Published in Toronto .

Written in English

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  • Cytosine,
  • Hydrates,
  • Photochemistry

Edition Notes

Book details

ContributionsToronto, Ont. University.
The Physical Object
Paginationiv, [3], 120 leaves.
Number of Pages120
ID Numbers
Open LibraryOL19696007M

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Cytosine (/ ˈ s aɪ t ə ˌ s iː n,-ˌ z iː n,-ˌ s ɪ n /; C) is one of the four main bases found in DNA and RNA, along with adenine, guanine, and thymine (uracil in RNA).

It is a pyrimidine derivative, with a heterocyclic aromatic ring and two substituents attached (an amine group at position 4 and a keto group at position 2). The nucleoside of cytosine is Watson-Crick base Chemical formula: C₄H₅N₃O. Cytosine arabinoside is extensively anabolized in cells; the mono- di- and triphosphate derivatives are formed and some incorporation into internal nucleotides in DNA occurs.

The drug-induced inhibition of DNA synthesis has been attributed to the competitive inhibition of DNA polymerase by cytosine arabinoside triphosphate (41, 42). D.J. Brown, in Comprehensive Heterocyclic Chemistry, Cytosine [4-aminopyrimidin-2(1H)-one]. Cytosine was isolated from hydrolysis of calf thymus in and by its structure was known and it had been synthesized from 2-ethylthiopyrimidin-4(3 H) acid hydrolysis of ribonucleic acid gives nucleotides, among which are two cytidylic acids, 2′- and 3′-phosphates of.

Cytarabine, also known as cytosine arabinoside (ara-C), is a chemotherapy medication used to treat acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and non-Hodgkin's lymphoma. It is given by injection into a vein, under the skin, or into the cerebrospinal fluid.

There is a liposomal formulation for which there is tentative evidence of better Pregnancy category: AU: D, US: D (Evidence of risk).

1. Biochim Biophys Acta. Mar 19;(1) Hydrogen exchange in photohydrates of cytosine derivatives. DeBoer G, Johns HE. PMID: Cited by: Epigenetic effects of cytosine derivatives are caused by their tautomers in Hoogsteen base pairs Denis Semyonov.

E-mail address: [email protected] Summary. Deoxycitidine in solution exists as two tautomers one of which is an “uncanonical” imino one. The latter can dominate with such derivatives as 5-methyl, 5-hydroxymethyl- and 5-formylcytosine. Biochim Biophys Acta. Jun 25; [Studies on the formation of N1-oxides of cytosine and cytosine derivatives].

[Article in German]Cited by: 1. Cytosine is an important part of DNA and RNA, where it is one of the nitrogenous bases coding the genetic information these molecules carry.

Cytosine can even be modified into different bases to. Study of Photochemical Cytosine to Uracil Transition via Ultrafast Photo-Cross-Linking Using Vinylcarbazole Derivatives in Duplex DNA Article (PDF Available) in Molecules 23(4) April with.

Cytosine is a pyrimidine base found in DNA and RNA that pairs with guanine. Cytosine is an aminopyrimidine that is pyrimidinone having the amino group located at position 4. It has a role as a human metabolite, an Escherichia coli metabolite, a Saccharomyces cerevisiae metabolite and a mouse metabolite.

It is a pyrimidine nucleobase, a. A) the nucleotide at the 3' end has a phosphate at its 3' hydroxyl. B) the nucleotide at the 3' end is a purine. C) the nucleotide at the 5' end has a 5' hydroxyl. D) the nucleotide at the 5' end has a phosphate on its 5' hydroxyl. E) the nucleotide at the 5' end is a pyrimidine.

Abstract. Amongst the most important detrimental effects of light on living systems are mutations, aging, and carcinogenesis.

In order to study these effects of light on man it is necessary to focus attention upon the effect of UV light on the genetic material, namely, by: However, these bonds would form only between certain base pairs- Adenine with thymine, and guanine with cytosine.

Base Pairing The ability of Studies on the photohydrates of cytosine and its derivatives. book model to explain Chargaff''s observations increased Watson and Crick's confidence that they had come to the.

(also 2-hydroxyaminopyrimidine), a natural organic compound. A pyrimidine base, cytosine occurs as white crystals or thin, lustrous platelets.

Its molecular weight is It is found in all living cells as a component of nucleotides—that is, compounds that form nucleic acids, coenzymes, and certain other biologically active substances.

However, the present quantum chemical study shows that the formation of thymine is limited because of the inefficiency of the methylation of pyrimidine and its oxidized derivatives in an H{sub 2}O ice, as supported by the laboratory studies.

Assessment of Cytosine Arabinoside as an Antiviral Agent in Humans Article (PDF Available) in Antimicrobial Agents and Chemotherapy 6(5) December with 24. Cytosine, a nitrogenous base derived from pyrimidine that occurs in nucleic acids, the heredity-controlling components of all living cells, and in some coenzymes, substances that act in conjunction with enzymes in chemical reactions in the body.

Cytosine is one of several types of bases that are incorporated into the nucleic acid c acids are composed of a five-carbon sugar. Cytosine is one of the 5 main nucleobases used in storing and transporting genetic information within a cell in the nucleic acids DNA and RNA.

In DNA and RNA, cytosine is paired with r, it is unstable, and can change into uracil (spontaneous deamination).This can lead to a point mutation if not repaired by the DNA repair enzymes such as uracil glycosylase, which cleaves a uracil Chemical formula: C₄H₅N₃O.

cytosine (sī′tə-sēn′) n. Abbr. C A pyrimidine base, C4H5N3O, that is the constituent of DNA and RNA involved in base-pairing with guanine.

[cyt(o)- + (rib)os(e) + -ine.] cytosine (ˈsaɪtəsɪn) n (Biochemistry) a white crystalline pyrimidine occurring in nucleic acids; 6-aminohydroxy pyrimidine. Formula: C4H5N3O. See also DNA, RNA cy•to. In many organisms, nuclear DNA is methylated at cytosine residues, resulting in 5-methylcytosine.

The derivatives of purine are called adenine and guanine, and the derivatives of pyrimidine are called thymine, cytosine and uracil. In DNA the bases pair to form a ladder-like structure, with adenine paired with thymine and guanine with cytosine.

Cytosine (C) is one of the four main bases found in DNA and RNA, along with adenine, guanine, and thymine (uracil in RNA). Cytosine is a pyrimidine, which forms three hydrogen bonds to. Guanine can be hydrolyzed with strong acid to glycine, ammonia, carbon dioxide, and carbonguanine gets deaminated to become xanthine.

Guanine oxidizes more readily than adenine, the other purine-derivative base in DNA. Its high melting point of °C reflects the intermolecular hydrogen bonding between the oxo and amino groups in the molecules in the al formula: C₅H₅N₅O. The complementary strand would contain bases in the sequence thymine, guanine, guanine, and cytosine.

Further Explanation: The DNA or deoxyribonucleic acid is a structure composed of two strands both of which are arranged in a helix. Each strand is a long stretch of nucleotides that are linked to each other through a phosphodiester bond. Question: Cytosine pairs with.

Base Pairs: If you picture DNA strands as being like a ladder, the rungs of the ladder are made up of nucleic acid base pairs.

These studies show that sucrose breakdown and starch synthesis are restricted by the levels of adenine and uridine nucleotide cofactors. All three enzymes showed a marked preference for adenine over guanine nucleotides.

The deamination product of adenine is hypoxanthine, and hypoxanthine base pairs with cytosine rather than thymine. C (cytosine): C stands for cytosine, a DNA nucleotide that which is one member of the base pair in DNA consisting of guanine and cytosine. This base pair is conventionally abbreviated G-C (or GC).

The other base pair in DNA is adenine and thymine which is conventionally abbreviated A-T (or AT). Jiali Gao received a B.S. in Chemistry from Beijing University in He came to Purdue University through a Graduate Program of 43 students, arranged by William von E. Doering, and obtained a Ph.D. in under the guidance of William L.

Jorgensen. DNA, light, and Dewar pyrimidinones: the structure and biological significance to TpT3. Medical Definition of Cytosine (C) Medical Author: William C. Shiel Jr., MD, FACP, FACR; Coronavirus COVID Latest News and Information. Cytosine (C): One member of the G-C (guanine-cytosine) pair of bases in DNA.

CONTINUE SCROLLING OR CLICK HERE FOR RELATED SLIDESHOW. SLIDESHOW. Of the four nucleobases in DNA, cytosine is the simplest to model. Its angular geometry is two dimensional and it has just a single six-sided ring.

Here's the molecular model done the Wikipedia way: It's not that hard to make a cytosine molecule from. The four nitrogenous bases in DNA are adenine, thymine, guanine and cytosine. DNA structure nucleic acid nucleotides hydrogen bond double helix deoxyribose adenine guanine thymine cytosine The structure of DNA is actually a fairly simple thing to understand but to begin with this we need to start off with what are the building blocks of DNA.

One acrylic ester of cytosine was synthesized by a facile method, and its molecular structure was characterized by NMR, HRMS, and X-ray crystallography.

In this paper, the crystal structure of the analog is described and the available data of cytosine. The X-ray crystallography showed that the adjacent molecule of cytosine Derivatives was tied to form analogous antiparallel β-sheet : Li Li Geng, Xue Min Ren, Wei Xi Mao, Xiao Ming Song, Yong Feng Ji, Wei Yuan.

The method of modification of heterocyclic bases of nucleic acids with chloroacetaldehyde and other α-halo carbonyl compounds is examined in this review. The mechanism, kinetics, and scope of the reaction, the chemical properties of modified derivatives of adenine and cytosine, and the possibilities of the application of etheno derivatives of adenine and cytosine in biochemistry and molecular Cited by: Cytosine is one of the four main bases found in DNA and RNA.

It is a pyrimidine derivative, with a heterocyclic aromatic ring and two substituents attached. The nucleoside of cytosine is cytidine. In Watson-Crick base pairing, it forms three hydrogen bonds with Full article >>> cytosine () n.

(Abbr. C) A pyrimidine base, C 4 H 5 N 3 O, that is the constituent of DNA and RNA involved in. A NEW SYNTHESIS OF CYTOSINE AND SMETHYLCYTOSINE BY GEORGE H. HITCHING& GERTRUDE B.

ELION, ELVIRA A. FALCO, AND PETER B. RUSSELL (From the Wellcome Research Laboratories, Tuckahoe, New York) (Received for publication, Septem ) The chief difficulty in the way of a fruitful synthesis of cytosine from.

Adenine - Cytosine - Cytosine - Guanine. Thymine - Guanine - Guanine - Cytosine. A base pair (bp) is the pairing of two nucleobases located on two complementary strands of DNA or RNA. This pairing is carried out by hydrogen bridges.

There are four types of nucleic bases: A-T-C-G, these letters for Adenine, Thymine, Cytosine and Guanine. Thymine is one of the four bases in the nucleic acid of DNA that are represented by the letters G–C–A–T.

The others are adenine, guanine, and cytosine. Thymine (T) always pairs with e is also known as 5-methyluracil, a pyrimidine nucleobase. As the name suggests, thymine may be derived by methylation of uracil at the 5th carbon.

In RNA. Cytosine is one of the 5 main nitrogenous bases used in storing and transporting genetic information within a cell. It is a pyrimidine derivative, with a heterocyclic aromatic ring and two substituents attached (an amine group at position 4 and a keto group at position 2).

The nucleoside of cytosine is cytidine. and thymine in a similar way and, because of its rapid growth, was used for enzymatic studies. It shows similar morphological properties to strain except that it retains Ziehl’s fuchsin after treatment wit.h 5 per cent sulfuric acid for several seconds.

It has a guanine + cytosine content of 42 %. It's difficult to see cytosine in a sentence. Its DNA is characterized by a 56 % guanine-cytosine content.

Sodium bisulfite is a chemical compound that converts unmethylated cytosines into uracil. Guanine is so, adenine la and cytosine do. Adenine pairs with thymine and guanine pairs with cytosine.

The chemical modification of DNA bases plays a key role in epigenetic gene regulation. While much attention has been focused on the classical epigenetic mark, 5-methylcytosine, the field garnered increased interest through the recent discovery of additional modifications.

In this review, we focus on the epigenetic regulatory roles of DNA modifications in by: guanine (gwä`nēn), organic base of the purine purine, type of organic base found in the nucleotides and nucleic acids of plant and animal tissue.

The German chemist Emil Fischer did much of the basic work on purines and introduced the term into the chemical literature in the early 20th cent.Cytosine Cytosine (C) is one of four chemical bases in DNA, the other three being adenine (A), guanine (G), and thymine (T).Within the DNA molecule, cytosine bases located on one strand form chemical bonds with guanine bases on the opposite strand.

Cytosine The other family of nitrogenous bases is pyrimidines. Cytosine is a pyrimidine; it has only one ring in its structure.

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